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Article

Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.

Gastroenterology - 1 Aug 2017

Yadav Pankaj, Ellinghaus David, Rémy Gaëlle, Freitag-Wolf Sandra, Cesaro Anabelle, Degenhardt Frauke, Boucher Gabrielle, Delacre Myriam, Peyrin-Biroulet Laurent, Pichavant Muriel, Rioux John D, Gosset Philippe, Franke Andre, Schumm L Philip, Krawczak Michael, Chamaillard Mathias, Dempfle Astrid, Andersen Vibeke

Abstract excerpt

BACKGROUND & AIMS: The role of tobacco smoke in the etiology of inflammatory bowel disease (IBD) is unclear. We investigated interactions between genes and smoking (gene-smoking interactions) that affect risk for Crohn's disease (CD) and ulcerative colitis (UC) in a case-only study of patients and in mouse models of IBD. METHODS: We used 55 Immunochip-wide datasets that included 19,735 IBD cases (10,856 CD cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28506689
DOI: 10.1053/j.gastro.2017.05.010
PMCID: PMC5526723

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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