Article
Deletion of the cytoplasmic domain of N-cadherin reduces, but does not eliminate, traction force-transmission.
Biochemical and biophysical research communications - 30 Sept 2016
Lee Eliot, Ewald Makena L, Sedarous Mary, Kim Timothy, Weyers Brent W, Truong Rose Hong, Yamada Soichiro
Abstract excerpt
Collective migration of epithelial cells is an integral part of embryonic development, wound healing, tissue renewal and carcinoma invasion. While previous studies have focused on cell-extracellular matrix adhesion as a site of migration-driving, traction force-transmission, cadherin mediated cell-cell adhesion is also capable of force-transmission. Using a soft elastomer coated with purified N-cadherin as a...
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