Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling.

PloS one - 1 Jan 2021

Aladin Darwesh Mohideen Kaderbatcha, Chu Yeh Shiu, Shen Shuo, Robinson Robert Charles, Dufour Sylvie, Viasnoff Virgile, Borghi Nicolas, Thiery Jean Paul

Abstract excerpt

Cadherins control intercellular adhesion in most metazoans. In vertebrates, intercellular adhesion differs considerably between cadherins of type-I and type-II, predominantly due to their different extracellular regions. Yet, intercellular adhesion critically depends on actomyosin contractility, in which the role of the cadherin extracellular region is unclear. Here, we dissect the roles of the Extracellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium

Share to Epithelium

Share to HEK293 Cells

Share to Mechanical Phenomena

Share to Models, Molecular

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 34937057
DOI: 10.1371/journal.pone.0260593
PMCID: PMC8694416

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling.PMID 34937057Read ↗

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integritySemantic proximity Read ↗

Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongationSemantic proximity Read ↗

Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contractionSemantic proximity Read ↗

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and CancerSemantic proximity Read ↗

Brick Strex – A Robust Device Built of LEGO® Bricks for Mechanical Manipulation of CellsSemantic proximity Read ↗

Intercellular adhesion stiffness moderates cell decoupling on stiff substratesSemantic proximity Read ↗

Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and DifferentiationSemantic proximity Read ↗

Mechanical strengthening of cell-cell adhesion during mouse embryo compactionSemantic proximity Read ↗

Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin networkSemantic proximity Read ↗

AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubsSemantic proximity Read ↗

Tension monitoring during epithelial-to-mesenchymal transition links the switch of phenotype to expression of moesin and cadherins in NMuMG cells.Semantic proximity Read ↗

Cadherin mechanotransduction in tissue remodeling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.