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Article

α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength.

The Journal of biological chemistry - 15 Feb 2013

Thomas William A, Boscher Cécile, Chu Yeh-Shiu, Cuvelier Damien, Martinez-Rico Clara, Seddiki Rima, Heysch Julie, Ladoux Benoit, Thiery Jean Paul, Mege René-Marc, Dufour Sylvie

Abstract excerpt

Maintaining cell cohesiveness within tissues requires that intercellular adhesions develop sufficient strength to support traction forces applied by myosin motors and by neighboring cells. Cadherins are transmembrane receptors that mediate intercellular adhesion. The cadherin cytoplasmic domain recruits several partners, including catenins and vinculin, at sites of cell-cell adhesion. Our study used force...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23266828
DOI: 10.1074/jbc.M112.403774
PMCID: PMC3576099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength.PMID 23266828Read ↗

αE-catenin is an autoinhibited molecule that coactivates vinculin.Semantic proximity Read ↗

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The force-sensing device region of α-catenin is an intrinsically disordered segment in the absence of intramolecular stabilization of the autoinhibitory form.Semantic proximity Read ↗

α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.Semantic proximity Read ↗

Extracellular domains of E-cadherin determine key mechanical phenotypes of an epithelium through cell- and non-cell-autonomous outside-in signaling.Semantic proximity Read ↗

VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.Semantic proximity Read ↗

α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction.Semantic proximity Read ↗

α-Catenin contributes to the strength of E-cadherin-p120 interactions.Semantic proximity Read ↗

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