Article
Mechanical force affects expression of an in vitro metastasis-like phenotype in HCT-8 cells.
Biophysical journal - 20 Oct 2010
Tang Xin, Kuhlenschmidt Theresa B, Zhou Jiaxi, Bell Philip, Wang Fei, Kuhlenschmidt Mark S, Saif Taher A
Abstract excerpt
Cancer deaths are primarily caused by metastases, not by the parent tumor. During metastasis, malignant cells detach from the parent tumor, and spread through the circulatory system to invade new tissues and organs. The physical-chemical mechanisms and parameters within the cellular microenvironment that initiate the onset of metastasis, however, are not understood. Here we show that human colon carcinoma (HCT-8)...
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