Article
Lateral assembly of N-cadherin drives tissue integrity by stabilizing adherens junctions.
Journal of the Royal Society, Interface - 6 Mar 2015
Garg S, Fischer S C, Schuman E M, Stelzer E H K
Abstract excerpt
Cadherin interactions ensure the correct registry and anchorage of cells during tissue formation. Along the plasma membrane, cadherins form inter-junctional lattices via cis- and trans-dimerization. While structural studies have provided models for cadherin interactions, the molecular nature of cadherin binding in vivo remains unexplored. We undertook a multi-disciplinary approach combining live cell imaging of...
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