Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular contractility changes are sufficient to drive epithelial scattering.

Experimental cell research - 15 Aug 2014

Hoj Jacob P, Davis John A, Fullmer Kendra E, Morrell David J, Saguibo Nicholas E, Schuler Jeffrey T, Tuttle Kevin J, Hansen Marc D H

Abstract excerpt

Epithelial scattering occurs when cells disassemble cell-cell junctions, allowing individual epithelial cells to act in a solitary manner. Epithelial scattering occurs frequently in development, where it accompanies epithelial-mesenchymal transitions and is required for individual cells to migrate and invade. While migration and invasion have received extensive research focus, how cell-cell junctions are detached...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial-Mesenchymal Transition
Share to Focal Adhesions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Growth Factor

Share to Heterocyclic Compounds, 4 or More Rings

Share to Intercellular Junctions

Share to Myosin Type II

Share to rhoA GTP-Binding Protein

Share to Stress Fibers

Source

Identifiers

PMID: 24780819
DOI: 10.1016/j.yexcr.2014.04.011

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular contractility changes are sufficient to drive epithelial scattering.PMID 24780819Read ↗

Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling.Semantic proximity Read ↗

The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering.Semantic proximity Read ↗

Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.Semantic proximity Read ↗

Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.Semantic proximity Read ↗

SNAIL-induced epithelial-to-mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression.Semantic proximity Read ↗

Mechanotransduction of strain regulates an invasive phenotype in newly transformed epithelial cellsSemantic proximity Read ↗

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.Semantic proximity Read ↗

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Semantic proximity Read ↗

Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering.Semantic proximity Read ↗

The SH2-containing inositol 5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells.Semantic proximity Read ↗

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.Semantic proximity Read ↗

Micromechanical control of cell–cell interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.