Article
HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics.
Bioinformatics (Oxford, England) - 1 Jan 2017
Zheng Jie, Rodriguez Santiago, Laurin Charles, Baird Denis, Trela-Larsen Lea, Erzurumluoglu Mesut A, Zheng Yi, White Jon, Giambartolomei Claudia, Zabaneh Delilah, Morris Richard, Kumari Meena, Casas Juan P, Hingorani Aroon D, Evans David M, Gaunt Tom R, Day Ian N M
Abstract excerpt
MOTIVATION: Fine mapping is a widely used approach for identifying the causal variant(s) at disease-associated loci. Standard methods (e.g. multiple regression) require individual level genotypes. Recent fine mapping methods using summary-level data require the pairwise correlation coefficients ([Formula: see text]) of the variants. However, haplotypes rather than pairwise [Formula: see text], are the true...
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