Article
Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases.
Nature genetics - 1 Sept 2024
Yuan Kai, Longchamps Ryan J, Pardiñas Antonio F, Yu Mingrui, Chen Tzu-Ting, Lin Shu-Chin, Chen Yu, Lam Max, Liu Ruize, Xia Yan, Guo Zhenglin, Shi Wenzhao, Shen Chengguo, Daly Mark J, Neale Benjamin M, Feng Yen-Chen A, Lin Yen-Feng, Chen Chia-Yen, O'Donovan Michael C, Ge Tian, Huang Hailiang
Abstract excerpt
Genome-wide association studies (GWAS) of human complex traits or diseases often implicate genetic loci that span hundreds or thousands of genetic variants, many of which have similar statistical significance. While statistical fine-mapping in individuals of European ancestry has made important discoveries, cross-population fine-mapping has the potential to improve power and resolution by capitalizing on the...
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