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Article

Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits.

Scientific reports - 21 Mar 2018

Shirali Masoud, Knott Sara A, Pong-Wong Ricardo, Navarro Pau, Haley Chris S

Abstract excerpt

We propose a novel approach to analyze genomic data that incorporates haplotype information for detecting rare variants within a regional heritability mapping framework. The performance of our approach was tested in a simulation study based on human genotypes. The phenotypes were simulated by generating regional variance using either SNP(s) or haplotype(s). Regional genomic relationship matrices, constructed with...

Topics

Chromosome Mapping
Croatia
Genome, Human
Haplotypes
Humans
Models, Genetic
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Quantitative Trait Loci

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29563569
DOI: 10.1038/s41598-018-23307-4
PMCID: PMC5862984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29563569-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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