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Article

Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits.

Scientific reports - 21 Mar 2018

Shirali Masoud, Knott Sara A, Pong-Wong Ricardo, Navarro Pau, Haley Chris S

Abstract excerpt

We propose a novel approach to analyze genomic data that incorporates haplotype information for detecting rare variants within a regional heritability mapping framework. The performance of our approach was tested in a simulation study based on human genotypes. The phenotypes were simulated by generating regional variance using either SNP(s) or haplotype(s). Regional genomic relationship matrices, constructed with...

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Identifiers

PMID: 29563569
DOI: 10.1038/s41598-018-23307-4
PMCID: PMC5862984

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Source receipt: pubmed, retrieved 7 Sept 2026.

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