Article
Heterozygosity Ratio, a Robust Global Genomic Measure of Autozygosity and Its Association with Height and Disease Risk.
Genetics - 1 Nov 2016
Samuels David C, Wang Jing, Ye Fei, He Jing, Levinson Rebecca T, Sheng Quanhu, Zhao Shilin, Capra John A, Shyr Yu, Zheng Wei, Guo Yan
Abstract excerpt
Greater genetic variability in an individual is protective against recessive disease. However, existing quantifications of autozygosity, such as runs of homozygosity (ROH), have proved highly sensitive to genotyping density and have yielded inconclusive results about the relationship of diversity and disease risk. Using genotyping data from three data sets with >43,000 subjects, we demonstrated that an...
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