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Article

Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits.

Human molecular genetics - 15 Jan 2007

Campbell Harry, Carothers Andrew D, Rudan Igor, Hayward Caroline, Biloglav Zrinka, Barac Lovorka, Pericic Marijana, Janicijevic Branka, Smolej-Narancic Nina, Polasek Ozren, Kolcic Ivana, Weber James L, Hastie Nicholas D, Rudan Pavao, Wright Alan F

Abstract excerpt

The dramatic changes in human population structure over the last 200 years have resulted in significant levels of outbreeding, which, in turn, is predicted to lead to increased levels of individual genetic diversity (genome-wide heterozygosity, h). To investigate possible effects of these large demographic changes on global health, we studied the effect of h, measured as relative heterozygosity, h(R), on 15...

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PMID: 17220173
DOI: 10.1093/hmg/ddl473

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