Article
Genetic diversity is a predictor of mortality in humans.
BMC genetics - 29 Dec 2014
Bihlmeyer Nathan A, Brody Jennifer A, Smith Albert Vernon, Lunetta Kathryn L, Nalls Mike, Smith Jennifer A, Tanaka Toshiko, Davies Gail, Yu Lei, Mirza Saira Saeed, Teumer Alexander, Coresh Josef, Pankow James S, Franceschini Nora, Scaria Anish, Oshima Junko, Psaty Bruce M, Gudnason Vilmundur, Eiriksdottir Gudny, Harris Tamara B, Li Hanyue, Karasik David, Kiel Douglas P, Garcia Melissa, Liu Yongmei, Faul Jessica D, Kardia Sharon Lr, Zhao Wei, Ferrucci Luigi, Allerhand Michael, Liewald David C, Redmond Paul, Starr John M, De Jager Philip L, Evans Denis A, Direk Nese, Ikram Mohammed Arfan, Uitterlinden André, Homuth Georg, Lorbeer Roberto, Grabe Hans J, Launer Lenore, Murabito Joanne M, Singleton Andrew B, Weir David R, Bandinelli Stefania, Deary Ian J, Bennett David A, Tiemeier Henning, Kocher Thomas, Lumley Thomas, Arking Dan E
Abstract excerpt
BACKGROUND: It has been well-established, both by population genetics theory and direct observation in many organisms, that increased genetic diversity provides a survival advantage. However, given the limitations of both sample size and genome-wide metrics, this hypothesis has not been comprehensively tested in human populations. Moreover, the presence of numerous segregating small effect alleles that influence...
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