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Article

An Unbiased Estimator of Gene Diversity with Improved Variance for Samples Containing Related and Inbred Individuals of any Ploidy.

G3 (Bethesda, Md.) - 9 Feb 2017

Harris Alexandre M, DeGiorgio Michael

Abstract excerpt

Gene diversity, or expected heterozygosity (H), is a common statistic for assessing genetic variation within populations. Estimation of this statistic decreases in accuracy and precision when individuals are related or inbred, due to increased dependence among allele copies in the sample. The original unbiased estimator of expected heterozygosity underestimates true population diversity in samples containing...

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Identifiers

PMID: 28040781
DOI: 10.1534/g3.116.037168
PMCID: PMC5295611

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