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Article

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Aug 2016

Xu Huixin, Gelyana Eilrayna, Rajsombath Molly, Yang Ting, Li Shaomin, Selkoe Dennis

Abstract excerpt

UNLABELLED: Microglial dysfunction is increasingly recognized as a key contributor to the pathogenesis of Alzheimer's disease (AD). Environmental enrichment (EE) is well documented to enhance neuronal form and function, but almost nothing is known about whether and how it alters the brain's innate immune system. Here we found that prolonged exposure of naive wild-type mice to EE significantly altered microglial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27581448
DOI: 10.1523/JNEUROSCI.1023-16.2016
PMCID: PMC5005718

Genes

CCL3
CCL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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