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Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

14 Jun 2021

Abstract excerpt

Aggregation and accumulation of amyloid-β (Aβ) is a defining feature of Alzheimer's disease pathology. To study microglial responses to Aβ, we applied exogenous Aβ peptide, in either oligomeric or fibrillar conformation, to primary mouse microglial cultures and evaluated system-level transcriptional changes and then compared these with transcriptomic changes in the brains of CRND8 APP mice. We find that primary...

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PMID: 34127518
DOI: 10.26508/lsa.202101108

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