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Article

Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease.

Neuro-degenerative diseases - 1 Jan 2012

Biscaro Barbara, Lindvall Olle, Tesco Giuseppina, Ekdahl Christine T, Nitsch Roger M

Abstract excerpt

BACKGROUND: Activated microglia with macrophage-like functions invade and surround β-amyloid (Aβ) plaques in Alzheimer's disease (AD), possibly contributing to the turnover of Aβ, but they can also secrete proinflammatory factors that may be involved in the pathogenesis of AD. Microglia are known to modulate adult hippocampal neurogenesis. OBJECTIVES/METHODS: To determine the role of microglia on neurogenesis in...

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Identifiers

PMID: 22584394
DOI: 10.1159/000330363
PMCID: PMC7068786

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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