Article

Natural Microbial Enrichment Modulates Microglial States and Transcriptional Programs Relevant to Alzheimer’s Disease

2026-03-03

Abstract excerpt

<h4>ABSTRACT</h4> The diversity of environmental microbial exposure is a key driver of immune maturation and host defense; however, its impact on brain immunity and neurodegenerative diseases remains poorly documented. Here, we show that controlled indoor rewilding, by introducing a natural farm-like environment into laboratory housing, reshapes peripheral and central nervous system (CNS) immune networks in wild-...

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Literature Corpus work: 83e41891-7b5a-5b73-99cb-717325016efc
DOI: 10.64898/2026.02.28.708710

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