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Article

Moderate environmental enrichment mitigates tauopathy in a neurofibrillary tangle mouse model.

Journal of neuropathology and experimental neurology - 1 Jul 2011

Lahiani-Cohen Inbal, Lourbopoulos Athanasios, Haber Ester, Rozenstein-Tsalkovich Lea, Abramsky Oded, Grigoriadis Nikolaos, Rosenmann Hanna

Abstract excerpt

Epidemiological studies show that stimulating activities reduce the risk of dementia. In animal models of Alzheimer disease, there have been conflicting results of the effects of environmental enrichment (EE) on disease-related amyloid pathology. Here, we tested the direct effect of EE, independently of amyloid pathology, on brain neurofibrillary tangles (NFTs), which best correlate with dementia. We exposed...

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PMID: 21666497
DOI: 10.1097/NEN.0b013e318221bfab

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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