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Article

Iso-α-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer's Disease.

The Journal of biological chemistry - 3 Mar 2017

Ano Yasuhisa, Dohata Atsushi, Taniguchi Yoshimasa, Hoshi Ayaka, Uchida Kazuyuki, Takashima Akihiko, Nakayama Hiroyuki

Abstract excerpt

Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long, healthy life. Here we found that iso-α-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor γ. In normal mice, oral administration of...

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PMID: 28087694
DOI: 10.1074/jbc.M116.763813
PMCID: PMC5339755

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