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Article

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.

The European journal of neuroscience - 1 Jul 2007

Dong Suzhen, Li Chunxia, Wu Pu, Tsien Joe Z, Hu Yinghe

Abstract excerpt

Presenilin (PS) 1 and 2 conditional double knockout (cDKO) mice show progressive memory dysfunction and forebrain degeneration. Gene expression profiling results revealed a strong activation of immunity and inflammation responses in the brains of 10-month-old cDKO mice. As environmental enrichment (EE) has been shown to be able to improve memory and induce neurogenesis of the brain, we assessed the effects of EE...

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Identifiers

PMID: 17614943
DOI: 10.1111/j.1460-9568.2007.05641.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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