A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED.

doi:10.1164/rccm.201512-2452OC

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Article

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED.

American journal of respiratory and critical care medicine - 15 Feb 2017

Kuo Chih-Hsi Scott, Pavlidis Stelios, Loza Matthew, Baribaud Fred, Rowe Anthony, Pandis Ioannis, Hoda Uruj, Rossios Christos, Sousa Ana, Wilson Susan J, Howarth Peter, Dahlen Barbro, Dahlen Sven-Erik, Chanez Pascal, Shaw Dominick, Krug Norbert, Sandstrӧm Thomas, De Meulder Bertrand, Lefaudeux Diane, Fowler Stephen, Fleming Louise, Corfield Julie, Auffray Charles, Sterk Peter J, Djukanovic Ratko, Guo Yike, Adcock Ian M, Chung Kian Fan

Abstract excerpt

RATIONALE: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. OBJECTIVES: Using transcriptomic profiling of airway tissues, we sought to define the molecular phenotypes of severe asthma. METHODS: The transcriptome derived from bronchial biopsies and epithelial brushings of 107 subjects with moderate to severe asthma were annotated by gene set variation analysis using 42...

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PMID: 27580351
DOI: 10.1164/rccm.201512-2452OC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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