Article

Novel Type 2-high gene clusters associated with corticosteroid sensitivity in COPD

2020-01-23

Abstract excerpt

<h4>Rationale</h4> Severe asthma and COPD share common pathophysiologic traits such as relative corticosteroid insensitivity. We recently published three transcriptome-associated clusters (TACs) using hierarchical analysis of the sputum transcriptome in asthmatics from the U-BIOPRED cohort with one Type 2-high signature (TAC1) and 2 Type 2-low signatures. <h4>Objective</h4> We examined whether gene-expression si...

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Literature Corpus work: 1af0097e-49c8-527b-a823-78d1a9b97f70
DOI: 10.1101/2020.01.22.912022

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