Article
Gene signatures in U-BIOPRED severe asthma for molecular phenotyping and precision medicine: time for clinical use.
Expert review of respiratory medicine - 1 Jan 2000
Kermani Nazanin, Versi Ali, Gay Aurore, Vlasma Jelmer, Jayalatha Akshaya Keerthi Saikumar, Koppelman Gerard H, Nawijn Martijn, Faiz Alen, van den Berge Maarten, Adcock Ian M, Chung Kian Fan
Abstract excerpt
INTRODUCTION: The use and generation of gene signatures have been established as a method to define molecular endotypes in complex diseases such as severe asthma. Bioinformatic approaches have now been applied to large omics datasets to define the various co-existing inflammatory and cellular functional pathways driving or characterizing a particular molecular endotype. AREAS COVERED: Molecular phenotypes and...
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