Article
Multidimensional endotyping using nasal proteomics predicts molecular phenotypes in the asthmatic airways.
The Journal of allergy and clinical immunology - 1 Jan 2023
Agache Ioana, Shamji Mohamed H, Kermani Nazanin Zounemat, Vecchi Giulia, Favaro Alberto, Layhadi Janice A, Heider Anja, Akbas Didem Sanver, Filipaviciute Paulina, Wu Lily Y D, Cojanu Catalina, Laculiceanu Alexandru, Akdis Cezmi A, Adcock Ian M
Abstract excerpt
BACKGROUND: Unsupervised clustering of biomarkers derived from noninvasive samples such as nasal fluid is less evaluated as a tool for describing asthma endotypes. OBJECTIVE: We sought to evaluate whether protein expression in nasal fluid would identify distinct clusters of patients with asthma with specific lower airway molecular phenotypes. METHODS: Unsupervised clustering of 168 nasal inflammatory and immune...
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