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Article

Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma.

American journal of respiratory and critical care medicine - 15 Feb 2022

Tiotiu Angelica, Badi Yusef, Kermani Nazanin Zounemat, Sanak Marek, Kolmert Johan, Wheelock Craig E, Hansbro Philip M, Dahlén Sven-Erik, Sterk Peter J, Djukanovic Ratko, Guo Yike, Mumby Sharon, Adcock Ian M, Chung Kian Fan

Abstract excerpt

Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive immunity, but their involvement in severe asthma (SA) remains undefined. Objectives: We investigated the phenotypic characteristics of the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) asthma cohort by applying published MC activation signatures to the sputum cell transcriptome. Methods:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34813381
DOI: 10.1164/rccm.202102-0355OC

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