Pathway discovery using transcriptomic profiles in adult-onset severe asthma.

doi:10.1016/j.jaci.2017.06.037

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Article

Pathway discovery using transcriptomic profiles in adult-onset severe asthma.

The Journal of allergy and clinical immunology - 1 Apr 2018

Hekking Pieter-Paul, Loza Matt J, Pavlidis Stelios, de Meulder Bertrand, Lefaudeux Diane, Baribaud Fred, Auffray Charles, Wagener Ariane H, Brinkman Paul, Lutter Rene, Bansal Aruna T, Sousa Ana R, Bates Steve A, Pandis Yannis, Fleming Louise J, Shaw Dominique E, Fowler Stephen J, Guo Y, Meiser Andrea, Sun Kai, Corfield Julie, Howarth Peter H, Bel Elisabeth H, Adcock Ian M, Chung Kian Fan, Djukanovic Ratko, Sterk Peter J

Abstract excerpt

BACKGROUND: Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments. Gene set variation analysis is a statistical technique used to identify gene profiles in heterogeneous samples. OBJECTIVE: We sought to identify gene profiles...

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PMID: 28756296
DOI: 10.1016/j.jaci.2017.06.037

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