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Article

Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma.

American journal of respiratory and critical care medicine - 15 May 2015

Yan Xiting, Chu Jen-Hwa, Gomez Jose, Koenigs Maria, Holm Carole, He Xiaoxuan, Perez Mario F, Zhao Hongyu, Mane Shrikant, Martinez Fernando D, Ober Carole, Nicolae Dan L, Barnes Kathleen C, London Stephanie J, Gilliland Frank, Weiss Scott T, Raby Benjamin A, Cohn Lauren, Chupp Geoffrey L

Abstract excerpt

RATIONALE: The airway transcriptome includes genes that contribute to the pathophysiologic heterogeneity seen in individuals with asthma. OBJECTIVES: We analyzed sputum gene expression for transcriptomic endotypes of asthma (TEA), gene signatures that discriminate phenotypes of disease. METHODS: Gene expression in the sputum and blood of patients with asthma was measured using Affymetrix microarrays. Unsupervised...

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Identifiers

PMID: 25763605
DOI: 10.1164/rccm.201408-1440OC
PMCID: PMC4451618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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