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Article

Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma.

Acta neuropathologica communications - 31 Aug 2016

Ryall Scott, Krishnatry Rahul, Arnoldo Anthony, Buczkowicz Pawel, Mistry Matthew, Siddaway Robert, Ling Cino, Pajovic Sanja, Yu Man, Rubin Joshua B, Hukin Juliette, Steinbok Paul, Bartels Ute, Bouffet Eric, Tabori Uri, Hawkins Cynthia

Abstract excerpt

Paediatric brain tumours arising in the thalamus present significant diagnostic and therapeutic challenges to physicians due to their sensitive midline location. As such, genetic analysis for biomarkers to aid in the diagnosis, prognosis and treatment of these tumours is needed. Here, we identified 64 thalamic gliomas with clinical follow-up and characterized targeted genomic alterations using newly optimized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27577993
DOI: 10.1186/s40478-016-0353-0
PMCID: PMC5006436

Genes

BRAF
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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