Article
H3F3A K27M mutations in thalamic gliomas from young adult patients.
Neuro-oncology - 1 Jan 2014
Aihara Koki, Mukasa Akitake, Gotoh Kengo, Saito Kuniaki, Nagae Genta, Tsuji Shingo, Tatsuno Kenji, Yamamoto Shogo, Takayanagi Shunsaku, Narita Yoshitaka, Shibui Soichiro, Aburatani Hiroyuki, Saito Nobuhito
Abstract excerpt
INTRODUCTION: Mutations in H3F3A, which encodes histone H3.3, commonly occur in pediatric glioblastoma. Additionally, H3F3A K27M substitutions occur in gliomas that arise at midline locations (eg, pons, thalamus, spine); moreover, this substitution occurs mainly in tumors in children and adolescents. Here, we sought to determine the association between H3F3A mutations and adult thalamic glioma. METHODS: Genomic...
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