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Article

Soluble Neuregulin-1 from Microglia Enhances Amyloid Beta-induced Neuronal Death.

CNS & neurological disorders drug targets - 1 Jan 2016

Liew Hyunjeong, Kim Yun-Mi, Choi Hee Soon, Jang Ah Ram, Churchill David, Lee Sang Hyung, Suh Yoo-Hun

Abstract excerpt

Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-Daspartate receptor, which increases the expression of the β2 subunit of the γ- aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor. In the dentate gyrus of 14-month-old Tg2576 mice, NRG-1 was strongly expressed compared with age-matched...

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Identifiers

PMID: 27577739
DOI: 10.2174/1871527315666160815160505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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