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Article

Neuregulin-1 regulates the conversion of M1/M2 microglia phenotype via ErbB4-dependent inhibition of the NF-κB pathway.

Molecular biology reports - 1 May 2022

Ma Yuqi, Fan Peixia, Zhao Rui, Zhang Yinghua, Wang Xianwei, Cui Weigang

Abstract excerpt

BACKGROUND: The inflammatory response caused by microglia in the central nervous system plays an important role in Alzheimer's disease. Neuregulin-1 (NRG1) is a member of the neuregulin family and has been demonstrated to have anti-inflammatory properties. The relationship between NRG1, microglia phenotype and neuroinflammation remains unclear. MATERIALS AND METHODS: BV2 cells were used to examine the mechanism...

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PMID: 35166983
DOI: 10.1007/s11033-022-07249-9

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