Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.

Journal of neuroscience research - 1 Sept 2003

Tsukamoto Emi, Hashimoto Yuichi, Kanekura Kohsuke, Niikura Takako, Aiso Sadakazu, Nishimoto Ikuo

Abstract excerpt

Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid-beta peptides (Abeta). Abeta binding to the 75-kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Abeta causes cell death in neuronal hybrid cells transfected with p75NTR, but not in nontransfected cells, and that p75NTR(L401K) cannot mediate Abeta neurotoxicity. We...

Topics

Join the communities discussing this publication.

Fibroblast Growth Factor 2
GTP-Binding Protein alpha Subunits, Gi-Go
Heterotrimeric GTP-Binding Proteins
Hybrid Cells
MAP Kinase Kinase 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Nerve Growth Factor

Receptors, Nerve Growth Factor

Source

Identifiers

PMID: 12929130
DOI: 10.1002/jnr.10703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.PMID 12929130Read ↗

Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons.Semantic proximity Read ↗

The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of beta-amyloid.Semantic proximity Read ↗

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.Semantic proximity Read ↗

?-amyloid binds to p75NTRand activates NF?B in human neuroblastoma cellsSemantic proximity Read ↗

Inactive variants of death receptor p75 <sup>NTR</sup> reduce Alzheimer’s neuropathology by interfering with APP internalizationSemantic proximity Read ↗

p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model.Semantic proximity Read ↗

A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality.Semantic proximity Read ↗

Abnormality of G-Protein-Coupled Receptor Kinases at Prodromal and Early Stages of Alzheimer's Disease: An Association with Early β-Amyloid AccumulationSemantic proximity Read ↗

Neurotoxic mechanisms by Alzheimer's disease-linked N141I mutant presenilin 2.Semantic proximity Read ↗

Death and survival of neuronal cells exposed to Alzheimer's insults.Semantic proximity Read ↗

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.Semantic proximity Read ↗

Soluble Neuregulin-1 from Microglia Enhances Amyloid Beta-induced Neuronal Death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.