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Article

Acquired QT interval prolongation and HERG: implications for drug discovery and development.

European journal of pharmacology - 1 Oct 2004

Finlayson Keith, Witchel Harry J, McCulloch James, Sharkey John

Abstract excerpt

Putative interactions between the Human Ether-a-go-go Related Gene (HERG), QT interval prolongation and Torsades de Pointes (TdP) are now integral components of any discussion on drug safety. HERG encodes for the inwardly rectifying potassium channel (I(Kr)), which is essential to the maintenance of normal cardiac function. HERG channel mutations are responsible for one form of familial long QT syndrome, a...

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Source

Identifiers

PMID: 15464027
DOI: 10.1016/j.ejphar.2004.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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