Article
Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.
Nature - 27 Mar 2014
Liu Xindong, Chen Xin, Zhong Bo, Wang Aibo, Wang Xiaohu, Chu Fuliang, Nurieva Roza I, Yan Xiaowei, Chen Ping, van der Flier Laurens G, Nakatsukasa Hiroko, Neelapu Sattva S, Chen Wanjun, Clevers Hans, Tian Qiang, Qi Hai, Wei Lai, Dong Chen
Abstract excerpt
In immune responses, activated T cells migrate to B-cell follicles and develop into follicular T-helper (TFH) cells, a recently identified subset of CD4(+) T cells specialized in providing help to B lymphocytes in the induction of germinal centres. Although Bcl6 has been shown to be essential in TFH-cell function, it may not regulate the initial migration of T cells or the induction of the TFH program, as...
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