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Article

GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors.

eNeuro - 1 Jan 2000

Meirsman Aura Carole, Robé Anne, de Kerchove d'Exaerde Alban, Kieffer Brigitte Lina

Abstract excerpt

GPR88 is an orphan G-protein-coupled receptor highly expressed in striatal dopamine D1 (receptor) R- and D2R-expressing medium spiny neurons. This receptor is involved in activity and motor responses, and we previously showed that this receptor also regulates anxiety-like behaviors. To determine whether GPR88 in D2R-expressing neurons contributes to this emotional phenotype, we generated conditional Gpr88...

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Share to Avoidance Learning
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Share to Conditioning, Psychological

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptor, Adenosine A2A

Share to Receptors, Dopamine D1

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Source

Open in PubMed Open full text

Identifiers

PMID: 27570825
DOI: 10.1523/ENEURO.0202-16.2016
PMCID: PMC4987659

Genes

GPR88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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