Article
Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82.
PloS one - 1 Jan 2011
Engel Kathrin M Y, Schröck Kristin, Teupser Daniel, Holdt Lesca Miriam, Tönjes Anke, Kern Matthias, Dietrich Kerstin, Kovacs Peter, Krügel Ute, Scheidt Holger A, Schiller Jürgen, Huster Daniel, Brockmann Gudrun A, Augustin Martin, Thiery Joachim, Blüher Matthias, Stumvoll Michael, Schöneberg Torsten, Schulz Angela
Abstract excerpt
G protein-coupled receptors (GPCR) are involved in the regulation of numerous physiological functions. Therefore, GPCR variants may have conferred important selective advantages during periods of human evolution. Indeed, several genomic loci with signatures of recent selection in humans contain GPCR genes among them the X-chromosomally located gene for GPR82. This gene encodes a so-called orphan GPCR with unknown...
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