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Article

Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8.

The European journal of neuroscience - 1 Jul 2005

Duvoisin Robert M, Zhang Connie, Pfankuch Timothy F, O'Connor Heather, Gayet-Primo Jacqueline, Quraishi Salma, Raber Jacob

Abstract excerpt

To study the role of the metabotropic glutamate receptor 8 (mGluR8), mice lacking this receptor were generated by homologous recombination. Homozygous mGluR8-deficient mice are about 8% heavier than their wild-type age-matched controls after reaching 4 weeks of age. This weight difference is not caused by an altered food intake and is not exacerbated by feeding the animals a high-fat diet. Moreover, mGluR8-/-...

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PMID: 16045496
DOI: 10.1111/j.1460-9568.2005.04210.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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