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Article

Normal Ethanol Sensitivity and Rapid Tolerance Require the G Protein Receptor Kinase 2 in Ellipsoid Body Neurons in Drosophila.

Alcoholism, clinical and experimental research - 1 Aug 2020

Kang Yuan Yuan, Wachi Yusuke, Engdorf Elizabeth, Fumagalli Emiliano, Wang Youyou, Myers Jennifer, Massey Shebna, Greiss Antony, Xu Shiyu, Roman Gregg

Abstract excerpt

BACKGROUND: G protein signaling pathways are key neuromodulatory mechanisms for behaviors and neurological functions that affect the impact of ethanol (EtOH) on locomotion, arousal, and synaptic plasticity. Here, we report a novel role for the Drosophila G protein-coupled receptor kinase 2 (GPRK2) as a member of the GRK4/5/6 subfamily in modulating EtOH-induced behaviors. METHODS: We studied the requirement of...

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PMID: 32573992
DOI: 10.1111/acer.14396
PMCID: PMC7485117

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