Article
Association of HLA genotypes with phenobarbital hypersensitivity in children.
Epilepsia - 1 Oct 2016
Manuyakorn Wiparat, Mahasirimongkol Surakameth, Likkasittipan Plernpit, Kamchaisatian Wasu, Wattanapokayakit Sukanya, Inunchot Wimala, Visudtibhan Anannit, Wichukchinda Nuanjun, Benjaponpitak Suwat
Abstract excerpt
OBJECTIVE: Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children. Clinical symptoms of phenobarbital hypersensitivity vary from maculopapular rashes (MPs) to severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Drug hypersensitivity...
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