Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis.

doi:10.1038/s41397-021-00247-3

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Article

Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis.

The pharmacogenomics journal - 1 Dec 2021

Sukasem Chonlaphat, Sririttha Suthida, Chaichan Chonlawat, Nakkrut Thapanat, Satapornpong Patompong, Jaruthamsophon Kanoot, Jantararoungtong Thawinee, Koomdee Napatrupron, Medhasi Sadeep, Oo-Puthinan Sarawut, Rerkpattanapipat Ticha, Klaewsongkram Jettanong, Rerknimitr Pawinee, Tuchinda Papapit, Chularojanamontri Leena, Tovanabutra Napatra, Suvannang Naravut, Rungrotmongkol Thanyada, Saokaew Surasak, Aekplakorn Wichai, Puangpetch Apichaya

Abstract excerpt

Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B (HLA-B) alleles have been linked to AEDs-induced cADRs. We investigated the association between cADRs (including Stevens-Johnson syndrome; SJS/toxic epidermal necrolysis; TEN, drug reaction with eosinophilia and systemic...

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PMID: 34175889
DOI: 10.1038/s41397-021-00247-3
PMCID: PMC8602035

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