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Article

Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2016

Wang Dong, Li Guo-Dong, Zhang Deng-Feng, Xu Ling, Li Xiao-An, Yu Xiu-Feng, Long Heng, Li Yu-Ye, Yao Yong-Gang

Abstract excerpt

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae), which has massive genomic decay and dependence on host metabolism. Accumulating evidence showed a crucial role of mitochondria in metabolism and innate immunity. We hypothesized that the mitochondrial-related antimicrobial/antiviral immune genes MAVS (mitochondrial antiviral signaling protein), MITA (mediator of IRF3 activation)...

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Source

Identifiers

PMID: 27553710
DOI: 10.1016/j.meegid.2016.08.021

Genes

MAVS
MFN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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