Article
A pathway-based association analysis identified FMNL1-MAP3K14 as susceptibility genes for leprosy.
Experimental dermatology - 1 Mar 2018
Zhang Huimin, Wang Zhenzhen, Fu Xi'an, Sun Yonghu, Mi Zihao, Yu Gongqi, Sun Lele, Wang Na, Wang Chuan, Zhao Qing, Pan Qing, Yue Zhenhua, Liu Hong, Zhang Furen
Abstract excerpt
The nuclear transcription factor-κB (NF-κB) plays a pivotal role in controlling both innate and adaptive immunity and regulates the expressions of many immunological mediators. Abundant evidences have showed the importance of NF-κB pathway in the host immune responses against Mycobacterium leprae in the development of leprosy. However, no particular association study between leprosy and NF-κB pathway-related gene...
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