Article
Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.
PLoS neglected tropical diseases - 1 May 2020
Leturiondo André Luiz, Noronha Ariani Batista, Mendonça Carla Yael Ribeiro, Ferreira Cynthia de Oliveira, Alvarado-Arnez Lucia Elena, Manta Fernanda Saloum de Neves, Bezerra Ohanna Cavalcanti de Lima, Carvalho Elizeu Fagundes de, Moraes Milton Ozório, Rodrigues Fabíola da Costa, Talhari Carolina
Abstract excerpt
Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, which affects skin and peripheral nerves. Polymorphisms in genes associated with autophagy, metabolism, innate and adaptive immunity confer susceptibility to leprosy. However, these associations need to be confirmed through independent replication studies in different ethnicities. The population from Amazon state (northern Brazil) is admixed...
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