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Article

The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China.

Journal of dermatological science - 1 Dec 2017

Wang Dong, Li Guo-Dong, Fan Yu, Zhang Deng-Feng, Bi Rui, Yu Xiu-Feng, Long Heng, Li Yu-Ye, Yao Yong-Gang

Abstract excerpt

BACKGROUND: The pathogen Mycobacterium leprae of leprosy is heavily dependent on the host energy metabolites and nutritional products for survival. Previously we and others have identified associations of several mitochondrion-related genes and mitochondrial DNA (mtDNA) copy number alterations with leprosy and/or its subtype. We hypothesized that genetic variants of mtDNA replication-related genes would affect...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase gamma

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Share to High-Throughput Nucleotide Sequencing

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Source

Identifiers

PMID: 28958595
DOI: 10.1016/j.jdermsci.2017.09.001

Genes

POLG
TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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