Epithelial tissue architecture protects against cancer.

Abstract excerpt

We consider the design of colon crypts from the point of view of minimizing the likelihood of generation of cancerous mutations. A stochastic mathematical model (a finite branching process) is developed and fully analyzed. It is found that depending on the mutation rates, different designs are evolutionarily advantageous. If the mutation rates associated with stem cells are a lot higher than the mutation rates of...

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