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Article

Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution.

PLoS computational biology - 1 Jan 2013

Zhao Rui, Michor Franziska

Abstract excerpt

Epithelial cells in the colon are arranged in cylindrical structures called crypts in which cellular proliferation and migration are tightly regulated. We hypothesized that the proliferation patterns of cells may determine the stability of crypts as well as the rates of somatic evolution towards colorectal tumorigenesis. Here, we propose a linear process model of colonic epithelial cells that explicitly takes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23785264
DOI: 10.1371/journal.pcbi.1003082
PMCID: PMC3681728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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