Article
Defining stem cell dynamics in models of intestinal tumor initiation.
Science (New York, N.Y.) - 22 Nov 2013
Vermeulen Louis, Morrissey Edward, van der Heijden Maartje, Nicholson Anna M, Sottoriva Andrea, Buczacki Simon, Kemp Richard, Tavaré Simon, Winton Douglas J
Abstract excerpt
Cancer is a disease in which cells accumulate genetic aberrations that are believed to confer a clonal advantage over cells in the surrounding tissue. However, the quantitative benefit of frequently occurring mutations during tumor development remains unknown. We quantified the competitive advantage of Apc loss, Kras activation, and P53 mutations in the mouse intestine. Our findings indicate that the fate...
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