Article
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.
Blood - 8 Jan 2015
Kernytsky Andrew, Wang Fang, Hansen Erica, Schalm Stefanie, Straley Kimberly, Gliser Camelia, Yang Hua, Travins Jeremy, Murray Stuart, Dorsch Marion, Agresta Sam, Schenkein David P, Biller Scott A, Su Shinsan M, Liu Wei, Yen Katharine E
Abstract excerpt
Mutations of IDH1 and IDH2, which produce the oncometabolite 2-hydroxyglutarate (2HG), have been identified in several tumors, including acute myeloid leukemia. Recent studies have shown that expression of the IDH mutant enzymes results in high levels of 2HG and a block in cellular differentiation that can be reversed with IDH mutant-specific small-molecule inhibitors. To further understand the role of IDH...
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