Article
Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.
Endocrinology - 1 Oct 2016
Dusaulcy Rodolphe, Handgraaf Sandra, Skarupelova Svetlana, Visentin Florian, Vesin Christian, Heddad-Masson Mounia, Reimann Frank, Gribble Fiona, Philippe Jacques, Gosmain Yvan
Abstract excerpt
Glucose homeostasis depends on the coordinated secretion of glucagon, insulin, and Glucagon-like peptide (GLP)-1 by pancreas and intestine. Obesity, which is associated with an increased risk of developing insulin resistance and type 2 diabetes, affects the function of these organs. Here, we investigate the functional and molecular adaptations of proglucagon-producing cells in obese mice to better define their...
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